UTSA vs. South Florida prediction: Odds, picks, best bet for Thursday’s AAC clash

UTSA vs. South Florida Prediction

UTSA and South Florida face off Thursday night in a critical American Athletic Conference (AAC) matchup. While both teams may finish the 2025 season short of their ultimate goals, each is among the top contenders in the Group of 5.

South Florida’s Season Overview

South Florida surprised many early in the season with wins over Boise State and Florida. However, a narrow loss to Memphis last week hurt their College Football Playoff chances. The AAC Championship is still within reach if USF wins out and receives some help from other teams.

UTSA’s Chances and Recent Performance

UTSA’s path to the AAC title is more challenging but remains possible if they defeat USF. Entering this game as a two-score underdog, the Roadrunners should not be underestimated. Week 10 showcased their potential when they overwhelmed Tulane 48-26 at the Alamodome, bouncing back from a heavy 55-17 loss to North Texas the previous week.

Strengths and Weaknesses

“The Roadrunners can light up a scoreboard with the best teams in the Group of 5, but the defense has been a mess all season.”

This game will highlight whether UTSA's offense can overcome its defensive vulnerabilities against a more balanced South Florida squad.

Author’s Summary

Both teams boast potent offenses but defensive inconsistencies will likely determine the outcome of this key AAC game.

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New York Post New York Post — 2025-11-06