Three infections, one fight: an implementation study to map needle prevalence and evaluate HIV, syphilis and hepatitis C prevention interventions in Regina, Saskatchewan – a protocol

Introduction

Saskatchewan is experiencing a public health crisis with rising rates of HIV, syphilis, and hepatitis C virus (HCV) infections, especially among people who use drugs. Injection drug use significantly contributes to these overlapping infections, worsened by structural challenges like stigma, poverty, and limited access to culturally safe healthcare. There is an urgent need for innovative, community-driven approaches to improve prevention, testing, and linkage to care.

Methods and Analysis

This study will introduce a rapid assessment and response system in Regina, Saskatchewan, combining geospatial mapping of needle prevalence with pop-up community interventions. Maps identifying needle hotspots will guide the setup of pop-up events that provide point-of-care testing for HIV, syphilis, and HCV, as well as education about pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP).

Study Design

A convergent participatory mixed-methods design will evaluate the intervention’s feasibility, acceptability, and effectiveness, using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework.

Data Collection

"This study integrates geospatial needle mapping with community-based interventions to address syndemic infections effectively."

Author's summary: This protocol outlines a rapid, community-informed strategy using needle mapping and pop-up testing to enhance prevention and care for HIV, syphilis, and hepatitis C among high-risk populations in Regina.

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BMJ Open BMJ Open — 2025-11-05

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