Long-Term Melatonin Use and Heart Risks
Long-term use of melatonin for sleep issues may carry unexpected cardiovascular dangers. Researchers observed that chronic melatonin users had nearly double the risk of death and were 3.5 times more likely to be hospitalized due to heart failure.
Study Findings on Melatonin and Heart Failure
A preliminary study presented at the American Heart Association's (AHA) Scientific Sessions 2025 revealed that adults with chronic insomnia using melatonin for a year or more were at greater risk of developing heart failure, requiring hospitalization for heart failure, and dying from any cause compared to non-users.
The study’s results were discussed at the AHA annual meeting held November 7-10 in New Orleans, a major event for updates on cardiovascular science and clinical research.
What Is Melatonin?
Melatonin is a hormone produced by the pineal gland that controls the body’s sleep-wake cycle. Its levels increase naturally at night and decrease during daylight. Synthetic melatonin, identical to the natural hormone, is commonly used to treat insomnia and jet lag.
Availability and Regulation
Melatonin supplements are available over the counter in many countries, including the U.S. However, since they are not regulated by the U.S. Food and Drug Administration, the purity and dosage of products can vary significantly.
Experts now advise caution when using melatonin for extended periods despite its widespread reputation as safe.
Chronic use of melatonin for sleep should be carefully considered due to potential serious heart-related risks uncovered by recent research.
Author's summary: New research warns that long-term melatonin use for sleep may increase serious heart risks, including heart failure and death, urging cautious use despite its common perception as safe.
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