## Objective
To evaluate whether cholinomimetic medication can reduce parotid gland enlargement caused by self-induced vomiting in bulimic patients.
## Background
Sialadenosis refers to non-inflammatory enlargement of the salivary glands, often seen in individuals with bulimia nervosa who frequently induce vomiting. This swelling primarily affects the parotid glands.
## Method and Findings
- The study explored the use of a cholinomimetic drug aimed at stimulating the parasympathetic nervous system to alleviate gland swelling.
- Results indicated a positive response in reducing parotid enlargement with medication.
> "Treatment with a cholinomimetic showed promise in resolving glandular swelling associated with bulimia-induced vomiting." — PS Mehler, 1993
## Clinical Implications
This approach offers a new therapeutic option targeting the physiological aspect of salivary gland hypertrophy in bulimia, potentially improving patient comfort and appearance.
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This study highlights a promising treatment to mitigate parotid gland enlargement in bulimia patients, suggesting pharmacological intervention may ease a distressing symptom of the disorder.
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JAMA — 2025-12-01