Impact of Smoking on Advanced Chronic Liver Disease Outcomes
Smoking in individuals with cirrhosis worsens inflammation, fibrogenesis, and angiogenesis, and increases the risk of extrahepatic cancers in advanced chronic liver disease (ACLD).
A study published in the Liver International journal found that smoking increases inflammation, fibrogenesis, and angiogenesis, as well as the risk for extrahepatic malignancies in ACLD.
According to the study, 40% of patients with ACLD have a history of smoking, yet little is known about the effects of smoking on ACLD outcomes.
- A single-center study (ClinicalTrials.gov Identifier: NCT03267615) investigated the impact of smoking on disease-driving mechanisms and clinical outcomes in ACLD.
- Eligible participants had a diagnosis of ACLD, based on a liver biopsy, liver stiffness measurement, or hepatic venous pressure gradient (HVPG).
No direct quote available in the given text.
Author's summary: Smoking worsens ACLD outcomes by increasing inflammation and cancer risk.
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