Advancing the Frontiers of Parkinson's Disease Research
Parkinson’s disease (PD) remains a challenging neurodegenerative disorder to diagnose and monitor.
Conventional clinical assessments and imaging often miss early molecular events, while overlapping symptoms with other synucleinopathies complicate diagnosis.
Alpha Synuclein Seed Amplification Assays
Alpha synuclein seed amplification assays (SAAs), including RT-QuIC, have emerged as diagnostic tools, detecting trace amounts of pathogenic aggregates with sensitivity and specificity.
These assays exploit the prion-like seeding behavior of misfolded alpha synuclein, enabling earlier and more accurate identification of disease-associated seeds.
By exploiting the prion-like seeding behavior of misfolded alpha synuclein, these assays detect trace amounts of pathogenic aggregates with exceptional sensitivity and specificity.
Author's summary: Parkinson's disease research advances with alpha synuclein seed amplification assays.
More News
- Who went home on 'Dancing with the Stars'? Elimination surprise on Rock & Roll Hall of Fame Night
- Robert Irwin ignites Paso Doble | TV Tonight
- Bridget Phillipson must not abandon special needs children | The Spectator Australia
- Stephen Curry scores 28 points, Moses Moody adds 24 as Warriors beat Suns 118-107
- Panthers to be tested by Wichita Carroll
- Between war and peace: future challenges in UK defence
- Democrats pick up seats in both Suffolk and Nassau legislatures
- Voting on Tuesday, the old-fashioned way
- Suffolk voters [reject/approve] ballot measure extending length of county legislative terms
- The Impact Collaborative (SSIR)